Effects of perioperative saphenous and sciatic nerve blocks,lumbosacral epidural or morphine–lidocaine–ketamine infusion on postoperative pain and sedation in dogs undergoing tibial plateau leveling osteotomy     

Alexandra B. Kalamaras  Turi K. Aarnes  Sarah A. Moore  Stephen C. Jones  Carolina Ricco Pereira  Juan Peng  Nina R. Kieves 《Veterinary anaesthesia and analgesia》2021,48(3):415-421

ObjectiveTo compare the quality of postoperative analgesia and sedation after preoperative saphenous and sciatic nerve blockade, preoperative lumbosacral epidural injection and perioperative intravenous (IV) morphine, lidocaine and ketamine infusions in dogs undergoing stifle arthroscopy and tibial plateau leveling osteotomy (TPLO) under general anesthesia.Study designProspective, blinded, randomized, clinical comparison study.AnimalsA total of 45 dogs weighing 33.9 (15.9–56.7) kg and aged 5.2 (1.0–12.0) years, mean (range), undergoing elective unilateral TPLO for spontaneous cranial cruciate ligament rupture.MethodsClient-owned dogs were enrolled. Dogs were randomly assigned to one of three groups: group MLK, perioperative IV morphine, lidocaine and ketamine infusion; group EPID, lumbosacral epidural with ropivacaine and morphine; or group SSNB, saphenous and sciatic nerve blockade with ropivacaine. Routine stifle arthroscopy followed by TPLO surgery was performed. Sedation and pain scores were assessed at 0, 2, 4, 8 and 24 hours following extubation. Rescue analgesia was administered as prescribed by Glasgow composite pain score–short form score >5.ResultsSedation scores for MLK were higher than EPID and SSNB. Pain scores for SSNB were lower than those for EPID and MLK. No significant differences were found in anesthesia duration or surgery duration among groups. No dogs required rescue analgesia.Conclusions and clinical relevanceAlthough analgesia was adequate in all groups, the best combination of analgesia without increased sedation was recorded for SSNB.  相似文献   

Surgical treatment of mammary carcinomas in dogs with or without postoperative chemotherapy          下载免费PDF全文

C. M. Tran  A. S. Moore  A. E. Frimberger 《Veterinary and comparative oncology》2016,14(3):252-262

This retrospective study identified prognostic factors associated with survival; and compared survival data in 94 canine mammary carcinoma (MCA) dogs treated with surgery (n = 58), or surgery and adjunct chemotherapy (n = 36), and a subset of dogs with poor prognostic factors. On multivariate analysis independent predictors of median survival time (MST) were clinical stage, lymphatic invasion (LI; present 179 days; none 1098 days), ulceration (present 118 days; none 443 days) and surgical margins (incomplete 70 days; complete 872 days). Complete surgical margins were associated with MST in dogs with stages 1–3 MCA (incomplete 68 days; complete 1098 days) and dogs with LI (incomplete 70 days; complete 347 days). There was no statistically significant improvement in MST in dogs with advanced disease (stage 4 or LI) treated with adjunctive chemotherapy (chemotherapy 228 days; none 194 days); although five dogs with complete surgical margins that received mitoxantrone and carboplatin had a mean survival of 1139 days.  相似文献   

Development and characterization of a technique for percutaneous radiologic gastrojejunostomy tube placement in the dog          下载免费PDF全文

Rebekah M. Mack DVM  DACVIM  Benjamin Staiger DVM  Daniel K. Langlois DVM  DACVIM  Stephen J. Mehler DVM  DACVS  Nathaniel Lam DVM  DACVS  Trevor Moore DVM  DACVIM  Andrew Brown DVM  DACVECC  DECVECC  Matthew W. Beal DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2016,26(5):646-653

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Serum,milk, and tissue monensin concentrations in cattle with adequate and potentially toxic dietary levels of monensin: pharmacokinetics and diagnostic interpretation          下载免费PDF全文

B. Puschner  A. C. Bautista  D. S. McKemie  S. M. Gallego  L. W. Woods  C. E. Moore  H. K. Knych 《Journal of veterinary pharmacology and therapeutics》2016,39(4):363-372

Used in both beef cattle and dairy cows, monensin can provide many health benefits but can, when unintended overexposures occur, result in adverse effects. Information on serum and tissue concentrations following overexposure and/or overt toxicosis which may aid in diagnostics and clinical outcome is lacking. The aim of this study was to determine concentrations of monensin in biological specimens following oral exposure for 10 days to an approved dose (1 mg/kg) and a higher dose (5 mg/kg) of monensin given daily on a body weight basis to 10 dairy cows. No deaths were reported; cows receiving 5 mg/kg showed early signs of toxicosis including depression, decreased feed intake, and diarrhea after 4 days of exposure. Histopathological findings were minimal in most cows. Pharmacokinetic modeling of the detected serum concentrations for the 1 and 5 mg/kg dose groups determined the C_max, T_max, and t_1/2λ to be 0.87 and 1.68 ng/mL, 2.0 and 1.0 h, and 1.76 and 2.32 days, respectively. Mixed regression models showed that the dose level and days since last dose were significantly associated with monensin concentrations in all four tissues, and with cardiac troponin levels. The high dose resulted in a significant elevation of monensin in tissues at approximately 4.7 times compared to the monensin concentrations in the tissues of animals from the low‐dose group. The cTnI concentrations in the high‐dose group were 2.1 times that of cTnI in the low‐dose group. Thus, the ability to diagnose monensin overexposure and/or toxicosis will improve from knowledge of biological monensin concentrations from this study.  相似文献   

Kinematic Magnetic Resonance Imaging for Evaluation of Disc‐Associated Cervical Spondylomyelopathy in Doberman Pinschers          下载免费PDF全文

M. Provencher  A. Habing  S.A. Moore  L. Cook  G. Phillips  R.C. da Costa 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(4):1121-1128

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Neutrophil myeloperoxidase measurements in plasma, laminar tissue, and skin of horses given black walnut extract     

Riggs LM  Franck T  Moore JN  Krunkosky TM  Hurley DJ  Peroni JF  de la Rebière G  Serteyn DA 《American journal of veterinary research》2007,68(1):81-86

OBJECTIVE: To compare measurements of myeloperoxidase (MPO) in plasma, laminar tissues, and skin obtained from control horses and horses given black walnut heartwood extract (BWHE). ANIMALS: 22 healthy 5- to 15-year-old horses. PROCEDURES: Horses were randomly assigned to 4 groups as follows: a control group given water (n = 5) and 3 experimental groups given BWHE (17) via nasogastric intubation. Experimental groups consisted of 5, 6, and 6 horses that received BWHE and were euthanatized at 1.5, 3, and 12 hours after intubation, respectively. Control horses were euthanatized at 12 hours after intubation. Plasma samples were obtained hourly for all horses. Laminar tissue and skin from the middle region of the neck were harvested at the time of euthanasia. Plasma and tissue MPO concentrations were determined via an ELISA; tissue MPO activity was measured by use of specific immunologic extraction followed by enzymatic detection. RESULTS: Tissues and plasma of horses receiving BWHE contained significantly higher concentrations of MPO beginning at hour 3. Laminar tissue and skin from horses in experimental groups contained significantly higher MPO activity than tissues from control horses. Concentrations and activities of MPO in skin and laminar tissues were similar over time. CONCLUSIONS AND CLINICAL RELEVANCE: In horses, BWHE administration causes increases in MPO concentration and activity in laminar tissue and skin and the time of increased MPO concentration correlates with emigration of WBCs from the vasculature. These findings support the hypothesis that activation of peripheral WBCs is an early step in the pathogenesis of acute laminitis.  相似文献   

Effects of a veterinary student leadership program on measures of stress and academic performance     

Moore DA  Truscott ML  St Clair L  Klingborg DJ 《Journal of veterinary medical education》2007,34(2):112-121

Assuming leadership roles in veterinary student governance or club activities could be considered an added stressor for students because of the impact on time available for personal and academic activities. The study reported here evaluated the effects of participation in a leadership program and leadership activity across two classes of veterinary students on measures of stress, using the Derogatis Stress Profile (DSP), and on veterinary school academic performance, measured as annual grade-point average (GPA) over a three-year period. Program participants and their classmates completed the DSP three times across the first three years of veterinary school. On average, participating students reported self-declared stress levels that were higher and measured DSP stress levels that were lower than those of the general population. Students were more likely to assume elected or appointed leadership roles while in their first three years of the veterinary degree program if they participated in the optional leadership program and demonstrated lower stress in several dimensions. Some increased stress, as measured in some of the DSP stress dimensions, had a small but statistically significant influence on professional school GPA. The study determined that the most important predictors of students' cumulative GPA across the three-year period were the GPA from the last 45 credits of pre-veterinary coursework and their quantitative GRE scores. The results of the study indicate that neither participation in the leadership program nor taking on leadership roles within veterinary school appeared to influence veterinary school academic performance or to increase stress.  相似文献   

The development of the normal Schirmer tear test results during the dog's first year of life     

Manuella Oliveira Borges de Sampaio  Bret A. Moore  Nathália Mendonça de Seabra  Mariza Bortolini  Thayane Cristina Vieira  Camilla Bolmann Martins  Ana Leticia Groszewicz de Souza  Camila Marinelli Martins  Fabiano Montiani-Ferreira 《Veterinary ophthalmology》2023,26(3):184-190

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Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion     

Jaya M. Mehra  M. Katherine Tolbert  Phillip Guadiano  Jörg M. Steiner  George E. Moore  Melissa J. Lewis 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):586-597

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David L. Brown and Kai A. Schafft: Rural people and communities in the twentyfirst century: resilience and transformation     

Lauren Renée Moore 《Agriculture and Human Values》2014,31(4):687-688

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